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Additional aspects include bioanalytical method development for Tox species and human (perhaps including key metabolites); documentation regarding toxicokinetics/exposure documentation (such as that involving safety pharmacology, genetic toxicology and repeated-dose toxicology)and human PK prediction (including bioavailability, allometric scaling and physiologically based pharmacokinetic (PBPK).
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The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science. Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within …
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Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.
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